Heart disease

Nephropathology

Head of Department:
Prof. Dr. med. Kerstin Amann

Heart Disease

Fig. 1: Collagen-stained (red) heart sections of SHAM-operated mice as well as Fn14 knockout (KO) und wildtype mice (WT) after experimental pressure-induced right ventricular hypertrophy (copyright: Novoyatleva et al., Basic Res Cardiol, 2013).
Fig. 2: Scheme of the mechanism by which F14 regulates fibrosis in experimental pressure-induced right ventricular hypertrophy (copyright: Novoyatleva et al., Basic Res Cardiol, 2013).

It is well known that the fetal gene program is partially re-activated under pathophysiological conditions including hypertrophy. However, the role of most of these genes is unknown. In addition, it is known that genes regulating cardiomyocyte proliferation during development induce often hypertrophy in the adult organism. Thus, we are interested to study proliferation-associated genes in adult cardiac diseases. In collaboration with Ralph Schermuly, we collected evidence that the receptor Fn14 that regulates cardiomyocyte proliferation during development is an important regulator of right heart disease.

 

Principal Investigator:

Prof. Dr. rer. nat. Felix Engel