Publikationen

Nephropathologie

Leiterin:
Prof. Dr. med. Kerstin Amann

2018

2017

2016

  • Mishra HK, Prots I, Havlicek S, Kohl Z, Perez-Branguli F, Boerstler T, Anneser L, Minakaki G, Wend H, Hampl M, Leone M, Brückner M, Klucken J, Reis A, Boyer L, Schuierer G, Behrens J, Lampert A, Engel FB, Gage FH, Winkler J, Winner B. GSK3ß-dependent dysregulation of neurodevelopment in SPG11-patient iPSC model. Ann Neurol 2016; doi: 10.1002/ana.24633. [Epub ahead of print]
  • Zebrowski DC, Becker R, Engel FB. Towards regenerating the mammalian heart: challenges in evaluating experimentally induced adult mammalian cardiomyocyte proliferation. Am J Physiol Heart Circ Physiol. 2016; ajpheart.00697.2015. doi: 10.1152/ajpheart.00697.2015. [Epub ahead of print]
  • Madonna R, Van Laake LW, Davidson SM, Engel FB, Hausenloy DJ, Lecour S, Leor J, Perrino C, Schulz R, Ytrehus K, Landmesser U, Mummery CL, Janssens S, Willerson J, Eschenhagen T, Ferdinandy P, Sluijter JPG. Position Paper of the ESC Working Group Cellular Biology of the Heart: Cell-Based Therapies for Myocardial Repair and Regeneration in Ischemic Heart Disease and Heart Failure. Eur Heart J. 2016; 37(23):1789-98. doi: 10.1093/eurheartj/ehw113
  • Wu CC, Kruse F, Vasudevarao MD, Junker JP, Zebrowski DC, Fischer K, Noël ES, Grün D, Berezikov E, Engel FB, van Oudenaarden A, Weidinger G, Bakkers J. Spatially Resolved Genome-wide Transcriptional Profiling Identifies BMP Signaling as Essential Regulator of Zebrafish Cardiomyocyte Regeneration. Dev Cell. 2016; 36(1):36-49. doi: 10.1016/j.devcel.2015.12.010
  • Andersen DC, Jensen CH, Baun C, Hvidsten S, Zebrowski DC, Engel FB, Sheikh SP. Persistent scarring and dilated cardiomyopathy suggest incomplete regeneration of the apex resected neonatal mouse myocardium - A 180days follow up study. J Mol Cell Cardiol. 2016; 90:47-52. doi: 10.1016/j.yjmcc.2015.11.031

2015

  • Soonpaa MH, Zebrowski DC, Platt C, Rosenzweig A, Engel FB, Field LJ. Cardiomyocyte Cell-Cycle Activity during Preadolescence. Cell 2015; 163(4):781-2. doi: 10.1016/j.cell.2015.10.037
  • Leone M, Magadum A, Engel FB. Cardiomyocyte proliferation in cardiac development and regeneration: a guide to methodologies and interpretations. Am J Physiol Heart Circ Physiol. 2015; 309(8):H1237-50. doi:10.1152/ajpheart.00559.2015
  • Zebrowski DC, Vergarajauregui S, Wu CC, Piatkowski T, Becker R, Leone M, Hirth S, Ricciardi F, Falk N, Giessl A, Just S, Braun T, Weidinger G, Engel FB. Developmental alterations in centrosome integrity contribute to the post-mitotic state of mammalian cardiomyocytes. Elife. 2015; 4. doi: 10.7554/eLife.05563
  • Roeder SS, Stefanska A, Eng DG, Kaverina NV, Sunseri MW, McNicholas BA, Rabinovitch P, Engel FB, Daniel C, Amann K, Lichtnekert J, Pippin JW, Shankland SJ. Changes In Glomerular Parietal Epithelial Cells In Mouse Kidneys With Advanced Age. Am J Physiol Renal Physiol. 2015; 309(2):F164-78. doi: 10.1152/ajprenal.00144.2015
  • Tallawi M, Zebrowski DC, Rai R, Roether JA, Schubert DW, Kozlowska A, El Fray M, Engel FB, Aifantis KE, Boccaccini AR. Poly(glycerol sebacate)/poly(butylene succinate-butylene dilinoleate) fibrous scaffolds for cardiac tissue engineering. Tissue Eng Part C Methods. 2015; 21(6):585-96. doi: 10.1089/ten.TEC.2014.0445
  • Ferrazzi F, Bellazzi RAR, Engel FB. Gene network analysis: from heart development to cardiac therapy. Thromb Haemost. 2015; 113(3):522-31. doi: 10.1160/TH14-06-0483
  • Patra C, Boccaccini AR, Engel FB. Vascularisation for cardiac tissue engineering: the extracellular matrix. Thromb Haemost. 2015; 113(3):532-47. doi: 10.1160/TH14-05-0480
  • Madonna R, Engel FB, Davidson SM, Ferdinandy P, Görbe A, Sluijter JP, Van Laake LW. Stem cell aging and age-related cardiovascular disease: Perspectives of treatment by ex-vivo stem cell rejuvenation. Curr Drug Targets. 2015; 16(8):780-5
  • Hamann J, Aust G, Araç D, Engel FB, Formstone C, Fredriksson R, Hall RA, Harty BL, Kirchhoff C, Knapp B, Krishnan A, Liebscher I, Lin HH, Martinelli DC, Monk KR, Peeters MC, Piao X, Prömel S, Schöneberg T, Schwartz TW, Singer K, Stacey M, Ushkaryov YA, Vallon M, Wolfrum U, Wright MW, Xu L, Langenhan T, Schiöth HB. International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G Protein–Coupled Receptors. Pharmacol Rev. 2015; 67(2):338-67. doi: 10.1124/pr.114.009647

2014

  • Sajjad A, Novoyatleva T, Vergarajauregui S, Troidl C, Schermuly RT, Tucker H, Engel FB. Lysine methyltransferase Smyd2 suppresses p53-dependent cardiomyocyte apoptosis. Biochim Biophys Acta. 2014; 1843(11):2556-62. doi: 10.1016/j.bbamcr.2014.06.019
  • Abdal-haya A, Vanegas B, Hamdy AS, Engel FB, Lim JH. Preparation and Characterization of Vertically Arrayed Hydroxyapatite Nanoplates on Electrospun Nanofibers for Bone Tissue Engineering. Chem Eng J. 2014; 254:612-622
  • Novoyatleva T, Sajjad A, Pogoryelov D, Patra C, Schermuly RT, Engel FB. FGF1-mediated cardiomyocyte cell cycle reentry depends on the interaction of FGFR-1 and Fn14. FASEB J. 2014; 28(6):2492-503. doi: 10.1096/fj.13-243576
  • Liebscher I, Ackley B, Araç D, Ariestanti DM, Aust G, Bae BI, Bista BR, Bridges JP, Duman JG, Engel FB, Giera S, Goffinet AM, Hall RA, Hamann J, Hartmann N, Lin HH, Liu M, Luo R, Mogha A, Monk KR, Peeters MC, Prömel S, Ressl S, Schiöth HB, Sigoillot SM, Song H, Talbot WS, Tall GG, White JP, Wolfrum U, Xu L, Piao X. New functions and signaling mechanisms for the class of adhesion G protein-coupled receptors. Ann N Y Acad Sci. 2014; 1333:43-64. doi: 10.1111/nyas.12580
  • Lecour S, Bøtker HE, Condorelli G, Davidson SM, Garcia-Dorado D, Engel FB, Ferdinandy P, Heusch G, Madonna R, Ovize M, Ruiz-Meana M, Schulz R, Sluijter JP, Van Laake LW, Yellon DM, Hausenloy DJ. ESC Working Group Cellular Biology of the Heart: Position Paper: improving the preclinical assessment of novel cardioprotective therapies. Cardiovasc Res. 2014; 104(3):399-411. doi: 10.1093/cvr/cvu225
  • Sluijter JPG, Condorelli G, Davidson SM, Engel FB, Ferdinandy P, Hausenloy DJ, Lecour S, Madonna R, Ovize M, Ruiz-Meana M, Schulz R, Van Laake LW. Novel Therapeutic Strategies for Cardioprotection. Pharmacol Ther. 2014; 144(1):60-70. doi: 10.1016/j.pharmthera.2014.05.005
  • Patra C, Monk KR, Engel FB. The multiple signaling modalities of adhesion G protein-coupled receptor GPR126 in development. Receptor Clin Invest. 2014; 1(3):79
  • Novoyatleva T, Sajjad A, Engel FB. TWEAK-Fn14 cytokine-receptor axis: a new player of myocardial remodeling and cardiac failure. Front Immunol. 2014; 5:50. doi: 10.3389/fimmu.2014.00050. eCollection 2014

2013

  • Samikannu B, Chen C, Lingwal N, Padmasekar M, Engel FB, Linn T. Dipeptidyl Peptidase IV inhibition activates CREB and improves islet vascularization through VEGF-A/VEGFR-2 signaling pathway. PLoS One. 2013; 8(12):e82639. doi: 10.1371/journal.pone.0082639. eCollection 2013
  • Mogha A, Benesh AE, Patra C, Engel FB, Schöneberg T, Liebscher I, Monk KR. Gpr126 functions in Schwann cells to control differentiation and myelination via G-protein activation. J Neurosci. 2013; 33(46):17976-85. doi: 10.1523/JNEUROSCI.1809-13.2013
  • Uosaki H, Magadum A, Seo K, Fukushima H, Takeuchi A, Nakagawa Y, Moyes KW, Narazaki G, Kuwahara K, Laflamme M, Matsuoka S, Nakatsuji N, Nakao K, Yamanaka S, Kwon C, Kass DA, Engel FB, Yamashita J. Identification of Chemicals Inducing Cardiomyocyte Proliferation in Developmental Stage-Specific Manner with Pluripotent Stem Cells. Circ Cardiovasc Genet. 2013; 6(6):624-33. doi: 10.1161/CIRCGENETICS.113.000330
  • Patra C, van Amerongen MJ, Ghosh S, Ricciardi F, Sajjad A, Novoyatleva T, Mogha A, Monk KR, Mühlfeld C, Engel FB. Organ-specific function of adhesion G protein-coupled receptor GPR126 is domain-dependent. Proc Natl Acad Sci U S A. 2013; 110(42):16898-903. doi: 10.1073/pnas.1304837110
  • Novoyatleva T, Janssen W, Wietelmann A, Schermuly RT, Engel FB. TWEAK/Fn14 axis is a positive regulator of cardiac hypertrophy. Cytokine. 2013; 64(1):43-5. doi: 10.1016/j.cyto.2013.05.009
  • Nikolić I, Stanković ND, Bicker F, Meister J, Braun H, Awwad K, Baumgart J, Simon K, Thal SC, Patra C, Harter PN, Plate KH, Engel FB, Dimmeler S, Eble JA, Mittelbronn M, Schäfer MK, Jungblut B, Chavakis E, Fleming I, Schmidt MHH. EGFL7 ligates αvβ3 integrin to enhance vessel formation. Blood. 2013; 121(15):3041-50. doi: 10.1182/blood-2011-11-394882
  • Novoyatleva T, Schymura Y, Janssen W, Strobl F, Swiercz JM, Patra C, Posern G, Wietelmann A, Zheng TS, Schermuly RT, Engel FB. Deletion of FN14 receptor protects from right heart fibrosis and dysfunction. Basic Res Cardiol. 2013; 108(2):325. doi: 10.1007/s00395-012-0325-x
  • Kundu B, Kurland NE, Bano S, Patra C, Engel FB, Yadavalli VK, Kundu SC. Silk proteins for biomedical applications: Bioengineering perspectives. Prog Polym Sci. 2013; 39:251-267
  • Zebrowski DC, Engel FB. The Cardiomyocyte Cell Cycle in Hypertrophy, Tissue Homeostasis, and Regeneration. Rev Physiol Biochem Pharmacol. 2013; 165:67-96. doi: 10.1007/112_2013_12

2010-2012

  • Patra C, Ricciardi F, Engel FB. The functional properties of nephronectin: An adhesion molecule for cardiac tissue engineering. Biomaterials. 2012; 33(17):4327-35. doi: 10.1016/j.biomaterials.2012.03.021
  • Patra C, Talukdar S, Novoyatleva T, Velagala SR, Mühlfeld C, Kundu B, Kundu SC, Engel FB. Silk protein fibroin from Antheraea mylitta for cardiac tissue engineering. Biomaterials. 2012; 33(9):2673-80. doi: 10.1016/j.biomaterials.2011.12.036
  • Araç D, Aust G, Calebiro D, Engel FB, Formstone C, Goffinet A, Hamann J, Kittel RJ, Liebscher I, Lin HH, Monk KR, Petrenko A, Piao X, Prömel S, Schiöth HB, Schwartz TW, Stacey M, Ushkaryov YA, Wobus M, Wolfrum U, Xu L, Langenhan T. Dissecting signaling and functions of adhesion G protein-coupled receptors. Ann N Y Acad Sci. 2012; 1276:1-25. doi: 10.1111/j.1749-6632.2012.06820.x
  • Patra C, Diehl F, Ferrazzi F, van Amerongen MJ, Novoyatleva T, Schaefer L, Mühlfeld C, Jungblut B, Engel FB. Nephronectin regulates atrioventricular canal differentiation via Bmp4-Has2 signaling in zebrafish. Development. 2011; 138(20):4499-509. doi: 10.1242/dev.067454
  • Ferrazzi F, Engel FB, Wu E, Moseman AP, Kohane IS, Bellazzi R, Ramoni MF. Inferring cell cycle feedback regulation from gene expression data.
    J
    Biomed Inform. 2011
    ; 44(4):565-75. doi: 10.1016/j.jbi.2011.02.002
  • Diehl F, Brown MA, van Amerongen MJ, Novoyatleva T, Wietelmann A, Harriss J, Ferrazzi F, Böttger T, Harvey RP, Tucker PW, Engel FB. Cardiac deletion of Smyd2 is dispensable for mouse heart development. PLoS One. 2010; 5(3):e9748. doi: 10.1371/journal.pone.0009748
  • van Amerongen MJ, Diehl F, Novoyatleva T, Patra C, Engel FB. E2F4 is required for cardiomyocyte proliferation. Cardiovasc Res. 2010; 86(1):92-102. doi: 10.1093/cvr/cvp383
  • Novoyatleva T, Diehl F, van Amerongen MJ, Patra C, Ferrazzi F, Bellazzi R, Engel FB. TWEAK is a positive regulator of cardiomyocyte proliferation. Cardiovasc Res. 2010; 85(4):681-90. doi: 10.1093/cvr/cvp360

2006-2008

  • Simonides WS, Mulcahey MA, Redout EM, Muller A, Zuidwijk MJ, Visser TJ, Wassen FWJS, Crescenzi A, da-Silva WS, Harney J, Engel FB, Obregon MJ, Larsen PR, Bianco AC, Huang SA. Hypoxia-inducible factor induces local thyroid hormone inactivation during hypoxic-ischemic disease in rats. J Clin Invest. 2008; 118(3):975-83. doi: 10.1172/JCI32824
  • van Amerongen MJ and Engel FB. Features of cardiomyocyte proliferation and its potential for cardiac regeneration. J Cell Mol Med. 2008; 12(6A):2233-44. doi: 10.1111/j.1582-4934.2008.00439.x
  • Schebesta M, Lien CL, Engel FB, Keating MT. Transcriptional profiling of caudal fin regeneration in zebrafish. ScientificWorldJournal. 2006; 6 Suppl 1:38-54
  • Engel FB, Hsieh PCH, Lee RT, Keating MT. FGF1/p38 MAP kinase inhibitor therapy induces cardiomyocyte mitosis, reduces scarring and rescues function after myocardial infarction. Proc Natl Acad Sci U S A. 2006;  103(42):15546-51 (co-corresponding author)
  • Tseng AS, Engel FB, Keating MT. The GSK-3 Inhibitor BIO Promotes Proliferation in Mammalian Cardiomyocytes. Chemistry & Biology. 2006; 13(9):957-63
  • Engel FB, Schebesta M, Keating MT. Anillin Localization Defect in Cardiomyocyte Binucleation. J Mol Cell Cardiol. 2006; 41(4):601-12

1999-2005

  • Engel FB, Schebesta M, Duong MT, Lu G, Ren S, Madwed JB, Jiang H, Wang Y, Keating MT. p38 MAP Kinase Inhibition Enables Proliferation of Adult Mammalian Cardiomyocytes. Genes & Dev. 2005; 19(10):1175-87
  • Engel FB. Cardiomyocyte Proliferation: A Platform for Mammalian Cardiac Repair. Cell Cycle. 2005; 4(10):1360-3
  • Philippar U, Schratt G, Dieterich C, Muller JM, Galgoczy P, Engel FB, Keating MT, Gertler F, Schule R, Vingron M, Nordheim A. The SRF Target Gene Fhl2 Antagonizes RhoA/MAL-Dependent Activation of SRF. Mol Cell. 2004; 16(6):867-80
  • Gresch O, Engel FB, Nesic D, Tran TT, England HM, Hickman ES, Körner I, Gan L, Chen S, Castro-Obregon S, Hammermann R, Wolf J, Müller-Hartmann H, Nix M, Siebenkotten G, Kraus G, Lun K. New non-viral method for gene transfer into primary cells. Methods, 2004; 33(2):151-63
  • Engel FB, Hauck L, Boehm M, Nabel EG, Dietz R, von Harsdorf R. P21CIP1 controls proliferating cell nuclear antigen protein level in adult cardiomyocytes. Mol Cell Biol. 2003; 23(2):555-65
  • Engel FB, Hauck L, Cardoso MC, Leonhardt H, Dietz R, von Harsdorf R. A mammalian myocardial cell-free system to study cell cycle reentry in terminally differentiated cardiomyocytes. Circ Res. 1999; 85(3):294-301

Philippar U, Schratt G, Dieterich C, Muller JM, Galgoczy P, Engel FB, Keating MT, Gertler F, Schule R, Vingron M, Nordheim A. The SRF Target Gene Fhl2 Antagonizes RhoA/MAL-Dependent Activation of SRF. Mol Cell. 2004; 16(6):867-80

 

Leitung:

Prof. Dr. rer. nat. Felix Engel