Faculty of Medicine, Friedrich-Alexander-University Erlangen-Nürnberg, Germany
A postdoctoral position is available in the group of Professor Felix B. Engel. The team studies heart development and applies this knowledge to enhance endogenous cardiac repair processes or to engineer cardiac tissues for transplantation. Main topics are currently adhesion GPCRs, cardiomyocyte proliferation, centrosome biology/non-centrosomal microtubule-organizing center, electroconductive hydrogels, and spider silk based materials. To achieve this, the group utilizes for example zebrafish and mouse as model organisms, hiPSCs, as well as state-of-the-art molecular and cell biology techniques. The Engel group is located in the Translational Research Center of the University Hospital Erlangen. Our laboratory publishes regularly in high profile journals such as Cell Research, Advanced Functional Materials, PNAS, eLife, Development, and Biomaterials.
Background of the project: Cardiomyocytes establish after birth a cell cycle arrest associated with cytokinesis failure and centrosome disintegration, which appears strict as cardiac tumors are very rare. In addition, it is extremely difficult to induce tumor-relevant processes like proliferation and migration in adult cardiomyocytes. Thus, we hypothesize that cardiomyocyte differentiation represent an excellent model to identify new potential targets to treat cancer.
Funding: The project is funded by the Wilhelm Sander-Foundation. Salary: E13, 100% for 2 years with possible extension.
Job description: We are seeking a highly motivated and ambitious postdoctoral candidate with a strong background in cell, developmental and/or molecular biology with experience in life cell imaging, the model system zebrafish and/or cancer biology to join our team. The candidate will investigate the effect of candidate genes obtained from studying heart development on colorectal cancer growth and metastasis in an embryonic zebrafish xenograft model and in vitro systems. Starting date for this position is the 1 July 2020, or upon agreement with the chosen candidate.
Application: Please contact Prof. Engel for further information and send your application preferable by email to:
Prof. Dr. rer. nat. Dipl. Ing. Felix B. Engel
Experimentelle Nieren- und Kreislaufforschung
Nephropathologische Abteilung, Pathologisches Institut
Schwabachanlage 12 (TRC)
phone: +49 (0) 9131-8525699
Deadline for applications: 9 May 2020, 23.59 pm.
We are open for new fellows. Possibilities are for example:
The Engel-Lab offers to host foreign fellows of the Alexander von Humboldt Foundation. More information one can find here.
Prof. Dr. rer. nat. Felix Engel