It is well known that the fetal gene program is partially re-activated under pathophysiological conditions including hypertrophy. However, the role of most of these genes is unknown. In addition, it is known that genes regulating cardiomyocyte proliferation during development induce often hypertrophy in the adult organism. Thus, we are interested to study proliferation-associated genes in adult cardiac diseases. In collaboration with Ralph Schermuly, we collected evidence that the receptor Fn14 that regulates cardiomyocyte proliferation during development is an important regulator of right heart disease.
Prof. Dr. rer. nat. Felix Engel