One major problem in the regeneration field is to get functional cells integrated into the target organ. And even if this can be achieved it appears to be difficult to get them incorporated to restore the tissue architecture. Thus, tissue engineering emerged as an important field to promote tissue regeneration. We are interested in identifying new suitable materials for cardiac tissue engineering and plan in the future to graft in vitro engineered tissues to the damaged heart. Recently, we have identified Nephronectin as a suitable cardiac adhesive and generated cardiac patches based on silk.